Abstract: Chemical flooding is one of the ways to improve oil recovery. In order to ensure the balanced displacement of chemical flooding and reduce the loss of chemical agents, based on the comprehensive consideration of the key parameters such as reasonable injection speed, well group pore volume, reasonable injection intensity, reasonable injection production ratio, injection production relationship, connectivity status, external water, etc., the workflow of rational production and injection allocation of chemical flooding and all injection on the well network are proposed. Besides, the calculation method of reasonable injection rate and reasonable liquid production rate of production wells are also proposed, which strongly supports the engineering design of chemical flooding reservoirs.