Abstract: In order to solve the problems of thin reservoir thickness,rapid change of facies belt and difficulty in hydrocarbon prediction in Niuju area,the prediction of favorable oil and gas bearing area in the first member of Shahejie formation is carried out by using oil and gas detection technology based on the theory of two-phase media.Firstly,the detection window is determined by fine well seismic calibration.Then,the multi-well spectrum comparison analysis is used to pick up the sensitive frequency band.Finally,according to the characteristics of "low frequency resonance and high frequency attenuation" of seismic wave propagation in two-phase media,the favorable oil and gas bearing area is predicted.The results show that the coincidence rate between the prediction results and drilling is up to 80%,which can provide technical support for the next exploration and deployment.