Abstract: PL oilfield has the characteristics of long oil-bearing intervals,large number of oil-bearing layers and rapid lateral change of reservoirs.As for the profile control technology of CO_2 generation in layers,it is necessary to optimize the profile control layers according to the characteristics of each layer in practical application.Based on fully considering the factors that affect the profile control layers,by determining the index set of decision-making and evaluation of profile control,the entropy method is used to determine the weight coefficient of evaluation index.When applying it to the improved TOPSIS multi-attribute decision-making method based on vertical distance,the comprehensive decision-making model of profile control layers is established.Through field application,the TOPSIS based on the entropy weight method is proved to be reliable in the decision-making results of profile control and layer selection.According to this model,the profile control operation of CO_2 generation in layers has been carried out for 35 well times in PL oilfield,which achieves increased injection of 41.7×10~4 m~3 and increased oil of 5.54×10~4 m~3.The remarkable effect provides a reference for similar oilfields.