Abstract: Multi-lateral horizontal well technology is important measure to enhance the production capability of difficult producing reserve and low speed development block.In the process of horizontal well drilling and completion,input fluid caused different immersion time for different position,which caused uneven distribution of damage belt.Therefore,even distribution acid of horizontal well section is key element to acidizing effect.Analysing damage features of Gaoshen oilfield Lei 52 horizontal wells,according to oil layer physical property,micelle acid fluid systematical formula is selected and sliding sleeve ball section acidizing technique is studied.After application of horizontal well section acidizing technology in Lei 52-Du H301 well,oil layer pollution is released,fluid production is enhanced in large scale,which realized the even distribution acid in screen completion multi-lateral horizontal well.