Abstract: After process modification, the application of acidification and plug removal technique of oil and water wells in low permeability sandstone reservoirs is invalid or not ideal, the flew out acid is difficult to treat and may cause environmental pollution. Based on the study of the rock minerals that make up the oil layer framework, the special acid of dissolving clay minerals and cement was developed. By considering the corrosion of external mechanical impurities, a matched supramolecular high temperature corrosion inhibitor and non-flow back process design was also developed, which provided a practical and effective non-flowback acidizing process for oil wells in the south of Linnan sub – sag. The field application indicates that supramolecular corrosion and scale inhibitor is selected to form a supramolecular film which is superior to Nano film on the metal surface, and the effect of corrosion and scale inhibition is close to 100%.