Abstract: In the article we inferred high water-intakepermeability formula through permeability velocity formula,then inferred water flood mixing response time to calculatepermeability. The calculated result is close to the resultshown by the tracer material. The parameter is easy to collect for this formula, and it is easy for operation. Simultaneously the formation large pore passage volume formula,plugging amount, construction displacement have been inferred. We proposed at first to pour small dosage highstrength plugging agent which can solidified in the stratuminto more slugs, then pour conventional profile control agent. The field application has shown effect.