Abstract: In view of the status and characteristics of injection-production structure in Henan oilfield, ways and methods to realize the target of water-cut control and production stabilization at late development stage with extra-high water-cut are summarized in this paper on the basis of practices of injection-production structure adjustment. Measures adopted in injection structure adjustment mainly are reducing the number of underinjec-tion layers, reducing and controlling irrational overinjec-tion layers and improving water absorption profile; measures taken in fluid production structure adjustment include controlling water injection in layers with high water-cut, strengthening water injection in low permeability layers, plugging highly permeable layers and watered out interference layers, putting layers with medium permeability into production and improving the status of unbalanced recovery in plane. Highly efficient development at late stage with high water-cut has been realized in Shuanghe oilfield through injection structure adjustment.