Abstract: One of the key implementation the integral fracturing technology is the multiple fracturing parameters optimization. Aiming at the problem of traditional single-variable optimization deficiencies, this paper proposes the Response Surface Methodology (RSM). For the horizontal-vertical well pattern integral fracturing parameters optimization in Daqing a low permeability Peripheral Oilfield, the BBD method is used for trial design and the RSM has been set up. Besides that, the significances and interactions have been analyzed, and the optimal fracturing parameters combination has been established. At the same time, good application results have been achieved in actual well network. The research shows based on the RSM to solve integral fracturing parameters optimization is feasible and effective, which is also good to avoid the limitations of traditional research methods.