Abstract: In order to find the "sweet spots" area for shale gas exploration and development, the middle and upper Ordovician in the western margin of Ordos basin is taken as the research object. Firstly, the corresponding relationship between high-quality shale and various rock physical parameters in the study area is established. Then, the "geological sweet spots" and "engineering sweet spots" of shale gas are predicted by using seismic prediction technology. Finally, the prediction results are comprehensively analyzed and evaluated. The results show that the porosity, brittleness index and total organic carbon content of the middle upper Ordovician Ulalik formation in the western margin of Ordos basin are relatively high, and the fractures are relatively developed, which is the "sweet spots" area for shale gas exploration.