Abstract: The lithofacies of the sedimentary reservoirs in the lower Es3 sub-member of KL16 structure in Laizhouwan sag is complex, and reservoir prediction is difficult. In order to solve this problem, under the guidance of seismic sedimentology theory, the minimum isochronous research unit is used as the framework, with the method of well-seismic combination, the attribute optimization is adopted to study the plane seismic facies. Combined with the colored inversion profile, the dual-domain and double-sided interpretation can be used for fine prediction of the phase-controlled reservoirs. The prediction results are in good agreement with the drilling results, which proves to have a good application value. It is concluded that the thick lacustrine carbonate development area in the west of the platform will be a favorable area for further exploration.