Abstract: Reservoirs in Zhangdian oilfield, a complicated fault block oilfield, are mainly of fault nose and fault-litholog-ic types, and show "imbricated" distribution. Three types of response features occur during waterflooding, with highly deviated directional wells as production wells and vertical wells as injectors. In combination with the characteristics of Zhangidan oilfield, such as low permeability, existence of fractures, strong water sensitivity and imbricated oil layers with small areas, the causes of these three response features are studied and corresponding measures are presented according to different well groups and different response types.